Department of Immunology

Martin Prlic, Ph.D.

ASSOCIATE MEMBER, VACCINE AND INFECTIOUS DISEASE DIVISION, FRED HUTCHINSON CANCER RESEARCH CENTER, AFFILIATE ASSOCIATE PROFESSOR, DEPARTMENT OF IMMUNOLOGY

Dr. Prlic earned his PhD from the University of Minnesota in 2004. He is currently an Associate Member in the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center. Dr. Prlic joined the University of Washington Department of Immunology as an Affiliate Associate Professor in 2018. Dr. Prlic is also affiliated with the UW Department of Global Health, as well as the Pathobiology and Molecular and Cellular Biology Programs.

CONTACT

Mail Stop: E5-110
Ph: 206.664.2216
Fax: 206.664.2209

RESEARCH AREAS

Cancer Immunology
Cancer Biology

LAB MEMBERS

Prlic Lab Members

LAB

Prlic Lab

PUBMED

Prlic on PubMed

RESEARCH

The Prlic Lab primarily studies T cell and innate-like T cell responses in mucosal tissues with a particular interest in understanding how these cells function in different inflammatory environments including infections and cancer.

By defining the functional plasticity and functional potential of T cells in health and a range of different disease states we aim to understand how we can manipulate these cells to our advantage. Our goal is to understand the molecular basis of cell activation and differentiation to learn how to manipulate the cells for therapeutic purposes and ultimately improve human health.

PUBLICATIONS

  1. Voillet V, Buggert M, Slichter CK, Berkson JD, Mair F, Addison MM, Dori Y, Nadolski G, Itkin MG, Gottardo R, Betts MR and Prlic M. Human MAIT cells exit peripheral tissues and re-circulate via lymph in steady state conditions (in press)
  2. Mair F and Prlic M. 28-color immunophenotyping of the human dendritic cell compartment Cytometry (advanced online Jan 2018) doi:10.1002/cyto.a.23331
  3. Mpina M, Maurice NJ, Yajima M, Slichter CK, Miller HW, Dutta M, McElrath MJ, Stuart KD, De Rosa SC, McNevin JP, Linsley PS, Abdulla S, Tanner M, Hoffman SL, Gottardo R, Daubenberger CA, Prlic MControlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations. J Immunol. 2017 Jul 1;199(1):107-118
  4. Slichter CK, Miller HW, McDavid A, Finak G, Seymour BJ, McNevin JP, Diaz G, Czartoski JL, McElrath MJ, Gottardo R and Prlic M. Distinct activation thresholds of human conventional and innate-like memory T-cells. JCI Insight. 2016;1(8):e86292.
  5. Zehn D, Roepke S, Weakly K, Bevan MJ, Prlic M. Inflammation and TCR signal strength determine the breadth of the T cell response in a bim-dependent manner.  J Immunol 192(1):200-205, 2014  [PMCID:  PMC3903384].
  6. Chu T, Tyznik AJ, †Roepke S, Berkley A, Woodward-Davis A, Pattacini L, Bevan MJ, Zehn D, Prlic M.  Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner.  Cell Rep 3(3):701-708, 2013  [PMCID:  PMC3628815].