Department of Immunology

Gerald T. Nepom, M.D., Ph.D.

MEMBER, BENAROYA RESEARCH INSTITUTE
AFFILIATE PROFESSOR, IMMUNOLOGY

Dr. Nepom received his Bachelor’s degree in Biochemistry from Harvard. He attended the UW, receiving his Ph.D. in Biochemistry in 1977 and his M.D. in 1978. After postdoctoral work in immunogenetics in the Department of Pathology at Harvard Medical School, he returned to Seattle, joining the Fred Hutchinson Cancer Research Center and the UW School of Medicine Faculty in 1982. Since 1985 he has been a Member of the Benaroya Research Institute at Virginia Mason where he served as director until 2015. He assumed leadership of the NIAID-sponsored Immune Tolerance Network (ITN) in 2010.

CONTACT INFO

Benaroya Research Institute at Virginia Mason
1201 Ninth Avenue
Seattle, WA 98101-2795
Phone: 206-342-6516
Fax: 206-342-6581

RESEARCH AREAS

Tolerance & Autoimmunity

LAB MEMBERS

Administrator
Mary Roy, mroy@immunetolerance.org

 

LAB

ACCEPTING NEW STUDENTS: NO

Benaroya Research

PUBMED

Gerald Nepom on PubMed

RESEARCH

Dr. Nepom’s interests are focused on identifying and understanding molecular and genetic mechanisms contributing to pathogenesis of autoimmune disorders and using this information to evaluate autoreactive T cell lineage and fate determination. Translational and clinical applications include development and use of immunological monitoring tools for predicting disease susceptibility and response to therapy in clinical trials, with special emphasis on type 1 diabetes.

PUBLICATIONS

    1. Huffaker MF, Sanda S, Chandran S, Chung SA, St Clair EW, Nepom GT, Smilek DE. Approaches to Establishing Tolerance in Immune Mediated Diseases. Front Immunol. 2021 Sep 20;12:744804. doi: 10.3389/fimmu.2021.744804. PMID: 34616405; PMCID: PMC8488342.
    2. Linsley PS, Greenbaum CJ, Nepom GT. Uncovering Pathways to Personalized Therapies in Type 1 Diabetes. Diabetes. 2021 Apr;70(4):831-841. doi: 10.2337/db20-1185. PMID: 33741606; PMCID: PMC7980192.
    3. Diggins KE, Serti E, Muir V, Rosasco M, Lu T, Balmas E, Nepom G, Long SA, Linsley PS. Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects. JCI Insight. 2021 Feb 8;6(3):e142680. doi: 10.1172/jci.insight.142680. PMID: 33351781; PMCID: PMC7934874.
    4. Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw AH, McGargill MA, Jin H, Boi SK, Speake C, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James EA, Nepom GT, Youngblood B. Beta cell-specific CD8<sup>+</sup> T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes. Nat Immunol. 2020 May;21(5):578-587. doi: 10.1038/s41590-020-0633-5. Epub 2020 Mar 30. PMID: 32231298; PMCID: PMC7183435.
    5. Wiedeman AE, Muir VS, Rosasco MG, DeBerg HA, Presnell S, Haas B, Dufort MJ, Speake C, Greenbaum CJ, Serti E, Nepom GT, Blahnik G, Kus AM, James EA, Linsley PS, Long SA. Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression. J Clin Invest. 2020 Jan 2;130(1):480-490. doi: 10.1172/JCI126595. PMID: 31815738; PMCID: PMC6934185.
    6. Chow IT, Gates TJ, Papadopoulos GK, Moustakas AK, Kolawole EM, Notturno RJ, McGinty JW, Torres-Chinn N, James EA, Greenbaum C, Nepom GT, Evavold BD, Kwok WW. Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes. Sci Adv. 2019 Aug 21;5(8):eaaw9336. doi: 10.1126/sciadv.aaw9336. PMID: 31457096; PMCID: PMC6703875.
    7. Winters A, Bahnson HT, Ruczinski I, Boorgula MP, Malley C, Keramati AR, Chavan S, Larson D, Cerosaletti K, Sayre PH, Plaut M, Du Toit G, Lack G, Barnes KC, Nepom GT, Mathias RA; Immune Tolerance Network LEAP Study Team. The MALT1 locus and peanut avoidance in the risk for peanut allergy. J Allergy Clin Immunol. 2019 Jun;143(6):2326-2329. doi: 10.1016/j.jaci.2019.02.016. Epub 2019 Feb 27. PMID: 30825465; PMCID: PMC6556406.
    8. Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, Bettelli E. Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance. J Immunol. 2019 Mar 1;202(5):1373-1382. doi: 10.4049/jimmunol.1801425. Epub 2019 Jan 25. PMID: 30683697; PMCID: PMC6481683.
    9. Renand A, Shamji MH, Harris KM, Qin T, Wambre E, Scadding GW, Wurtzen PA, Till SJ, Togias A, Nepom GT, Kwok WW, Durham SR. Synchronous immune alterations mirror clinical response during allergen immunotherapy. J Allergy Clin Immunol. 2018 May;141(5):1750-1760.e1. doi: 10.1016/j.jaci.2017.09.041. Epub 2017 Nov 9. PMID: 29128670; PMCID: PMC5938141.