Department of Immunology

Daniel J. Campbell, Ph.D.

MEMBER, BENAROYA RESEARCH INSTITUTE AND AFFILIATE PROFESSOR, IMMUNOLOGY

Dr. Campbell received his PhD in Molecular and Cell Biology at the University of California, Berkeley in 1998. Following a postdoctoral fellowship at Stanford, he joined the Benaroya Research Institute as Assistant Member in 2003.

CONTACT INFO

Benaroya Research Institute at Virginia Mason
1201 Ninth Avenue
Seattle, WA 98101-2795
Phone: 206-341-1055
Fax: 206-233-7543

RESEARCH AREAS

Tolerance & Autoimmunity
Molecular Immunology

LAB MEMBERS

Graduate Students
Jenna Sullivan, jsull72@uw.edu
Kristen Mittelsteadt, mittek@uw.edu

Postdoctoral Fellows
Mark Singh, msingh@benaroyaresearch.org

Laboratory Staff
Kerri Thomas, kthomas@benaroyaresearch.org
Thomas Duhen, Staff Scientist, tduhen@benaroyaresearch.org

LAB

Benaroya Research

PUBMED

Daniel J. Campbell

RESEARCH

The cells and tissues of the immune system are precisely organized to ensure the proper development, activation, function and regulation of diverse lymphocyte populations. Tissue and microenvironment selective lymphocyte homing is the basis for this organization, which in turn is mediated by lymphocyte expression of specific combinations of surface adhesion and chemoattractant receptors. Expression of these homing receptors therefore defines functionally specialized lymphocyte populations with unique tissue-tropisms.

We are interested in further exploring the relationship between lymphocyte function, homeostasis and localization. Using mouse models of autoimmunity, our goals are to track the differentiation and localization of various homing receptor-defined populations of CD4+ T cells, and to determine how each of these contributes to the function and regulation of immune responses in specific tissues. In addition, we seek to understand the signaling events and transcriptional networks that direct T cell expression of different homing receptor combinations, and therefore control ‘organ-specific’ immunity and autoimmunity. Our work promises to yield new insights into lymphocyte differentiation and function, and holds great potential for the therapeutic manipulation of lymphocyte responses in the context of chronic infection, autoimmunity and transplantation.

The Campbell Laboratory is taking students at this time.

PUBLICATIONS

  1. Srivastava S, Koch LK, Campbell DJ. IFNαR Signaling in Effector but Not Regulatory T Cells Is Required for Immune Dysregulation during Type I IFN-Dependent Inflammatory Disease. J Immunol. 2014 Sep 15;193(6):2733-42.
  2. Gratz IK, Campbell DJ. Organ-specific and memory Treg cells: specificity,development, function, and maintenance. Front Immunol. 2014 Jul 15;5:333.
  3. Duhen T, Campbell DJ. IL-1β promotes the differentiation of polyfunctional human CR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes. J Immunol. 2014 Jul 1;193(1):120-9
  4. Srivastava S, Koch MA, Pepper M, Campbell DJ. Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med. 2014 May 5;211(5):961-74
  5. Smigiel KS, Srivastava S, Stolley JM, Campbell DJ. Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev. 2014 May;259(1):40-59
  6. Campbell DJ. MyD88 and IL-1: loosening T(reg) cells’ firm grip. Trends Immunol. 2014 Mar;35(3):95-6
  7. Smigiel KS, Richards E, Srivastava S, Thomas KR, Dudda JC, Klonowski KD, Campbell DJ. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J Exp Med. 2014 Jan 13;211(1):121-36
  8. Shafiani S, Dinh C, Ertelt JM, Moguche AO, Siddiqui I, Smigiel KS, Sharma P, Campbell DJ, Way SS, Urdahl KB. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity. 2013 Jun 27;38(6):1261-70
  9. Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol. 2013 Apr;14(4):307-8
  10. Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ. T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2. Immunity. 2012 Sep 21;37(3):501-10
  11. Suscovich TJ, Perdue NR, Campbell DJ. Type-1 immunity drives early lethality in scurfy mice. Eur J Immunol. 2012 Sep;42(9): 2305-10
  12. Naik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W, Deming C, Quinones M, Koo L, Conlan S, Spencer S, Hall JA, Dzutsev A, Kong H, Campbell DJ, Trinchieri G, Segre JA, Belkaid Y. Compartmentalized control of skin immunity by resident commensals. Science. 2012 Aug 31;337(6098):1115-9