Department of Immunology

Leroy Hood, M.D., Ph.D.


Dr. Hood graduated from the California Institute of Technology (Caltech) with a BS in biology and received his M.D. from the Johns Hopkins Medical School. He returned to Caltech, completing his Ph.D. in 1968.  Dr. Hood is President of the Institute for Systems Biology and member of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.


Institute for Systems Biology
401 Terry Avenue N
Seattle, WA 98109
Phone: 206-732-1200
Fax: 206-732-1299


Molecular Immunology
Cancer Immunology


Hood Lab


Hood Group at the Institute for Systems Biology


Lee Hood on PubMed


Dr. Hood’s professional career began when he and his colleagues developed the DNA gene sequencer and synthesizer and the protein sequencer and synthesizer ––four instruments that paved the way for the successful mapping of the human genome and automating DNA sequencing, which revolutionized biomedicine and forensic science. Dr. Hood’s projects center on cancer biology (prostate, ovarian, breast and liver cancers), systems approach to prion disease in mice and prostate cancer, new strategies for obtaining blood biomarkers, and a systems approach to the differentiation of hematopoietic stem cells. He is also interested type I diabetes. Finally, Dr. Hood’s laboratory is developing new tools and applications for genomics (large-scale DNA sequencing), computation (various approaches to delineating and engineering biological networks), and nanotechnology measurements of blood proteins.


  1. Glusman G, Caballero J, Mauldin D, Hood L, Roach JC. VIAR: an accessible system for testing SNV novelty. Bioinformatics. 2011 Sep 28. PMID:21965822
  2. Roach JC, Glusman G, Hubley R, Montsaroff SZ, Holloway AK, Mauldin DE, Srivastava D, Garg V, Pollard KS, Galas DJ, Hood L, Smit AF. Chromosomal haplotypes by genetic phasing of human families. Am J Hum Genet. 2011 Sep 9;89(3):382-97. PMID: 21855840
  3. Etheridge A, Lee I, Hood L, Galas D, Wang K. Extracellular microRNA: A new source of biomarkers. Mutat Res. 2011 Mar 23. PMID: 21402084
  4. Lausted C, Hu Z, Hood L. Label-free detection with surface plasmon resonance imaging. Methods Mol Biol. 2011;723:321-33. PMID:21370074
  5. Hood L, Friend SH .Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol. 2011 Mar;8(3):184-7.PMID:21364692
  6. Yan X, Ma L, Yi D, Yoon JG, Diercks A, Foltz G, Price ND, Hood LE, Tian Q. A CD133-related gene expression signature identifies an aggressive glioblastoma subtype with excessive mutations. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1591-6. Epub 2011 Jan 10. PMID: 21220328