Department of Immunology

Immunology News

Congratulations to Caleb Stoltzfus PhD, researcher in the Gerner Lab! Dr. Stoltzfus is one of eight Washington Research Foundation Fellows named in 2019. Read more… 

Congratulations to Dr. Pamela J Fink, Professor Emeritus with the UW Department of Immunology! Dr. Fink is the 2019 recipient of the American  Association of Immunologists (AAI) Lifetime Achievement Award. This award is the highest honor bestowed by the AAI Council upon an AAI member. Read more…

UW Immunology

The Department of Immunology is a basic science department within the University of Washington, School of Medicine located in Seattle.

Our mission is to advance understanding of the function of the immune system in order to enhance our ability to fight infectious disease, cancer and autoimmune disease.  Basic research of all aspects of immunology is critical to this mission, as well as translational research to link our findings to the development of new therapies.

We hold diversity and inclusiveness as core values in our department and emphasize their importance throughout our research, education and practice. We strive to create a climate that fosters belonging, respect and value for all within our scientific community and the institution.

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Recent Publications

Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation
Michael A. Davis, Marian R. Fairgrieve, Andreas Den Hartigh, Olga Yakovenko, Bhargavi Duvvuri, Christian Lood, Wendy E. Thomas, Susan L. Fink, Michael Gale. Proceedings of the National Academy of Sciences Feb 2019, 201818598; DOI: 10.1073/pnas.1818598116

Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes
Holly M. Akilesh, Matthew B. Buechler, Jeffrey M. Duggan, William O. Hahn, Bharati Matta, Xizhang Sun, Griffin Gessay, Elizabeth Whalen, Michael Mason, Scott R. Presnell, Keith B. Elkon, Adam Lacy-Hulbert, Betsy J. Barnes, Marion Pepper, Jessica A. Hamerman. Science 11 Jan 2019: Vol. 363, Issue 6423, eaao5213 DOI: 10.1126/science.aao5213

Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation. PLoS Pathog 15(2): e1007593. Negash AA, Olson RM, Griffin S, Gale M Jr (2019).

Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models.
Sippel TR, Radtke S, Olsen TM, Kiem HP, Rongvaux A. Blood Adv. 2019 Feb 12;3(3):268-274. doi: 10.1182/bloodadvances.2018023887. No abstract available. PMID: 30696625

MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells.
Radtke S, Chan YY, Sippel TR, Kiem HP, Rongvaux A. Exp Hematol. 2019 Feb;70:31-41.e1. doi: 10.1016/j.exphem.2018.12.003. Epub 2018 Dec 25.
PMID: 30590092