Department of Immunology

Immunology News

UW Immunology Ranked No. 6 Among Global Universities
The UW Immunology Department is up four spots, now ranked No. 6 among some of the most prestigious Universities in the world. Read more…

Newsmakers: Pepper Lab research featured in Seattle Times Article: Monoclonal antibodies could fill the COVID-19 treatment gap until vaccines arrive — but at a cost. Read more…

Check out our new UW Immunology Research Presents recorded events geared toward the non-scientist. Discover how the immune system functions across various organs during infection, vaccination, and allergy… Read more…

UW Immunology

The Department of Immunology is a basic science department within the University of Washington, School of Medicine located in Seattle.

Our mission is to advance understanding of the function of the immune system in order to enhance our ability to fight infectious disease, cancer and autoimmune disease.  Basic research of all aspects of immunology is critical to this mission, as well as translational research to link our findings to the development of new therapies.

We hold diversity and inclusiveness as core values in our department and emphasize their importance throughout our research, education and practice. We strive to create a climate that fosters belonging, respect and value for all within our scientific community and the institution.

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Recent Publications

  1. Ruterbusch M, Pruner KB, Shehata L, Pepper M. Annu Rev Immunol. In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm. 2020 Apr 26;38:705-725. doi: 10.1146/annurev-immunol-103019-085803. PMID: 32340571
  2. Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw AH, McGargill MA, Jin H, Boi SK, Speake C, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James EA, Nepom GT, Youngblood B. Beta cell-specific CD8(+) T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes. Nat Immunol. 2020 May;21(5):578-587. doi: 10.1038/s41590-020-0633-5. Epub 2020 Mar 30. PubMed PMID: 32231298; PubMed Central PMCID: PMC7183435.
  3. Wiedeman AE, Muir VS, Rosasco MG, DeBerg HA, Presnell S, Haas B, Dufort MJ, Speake C, Greenbaum CJ, Serti E, Nepom GT, Blahnik G, Kus AM, James EA, Linsley PS, Long SA. Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression. J Clin Invest. 2020 Jan 2;130(1):480-490. doi: 10.1172/JCI126595. PubMed PMID: 31815738; PubMed Central PMCID: PMC6934185.
  4. McGinty JW, Ting HA, Billipp TE, Nadjsombati MS, Khan DM, Barrett NA, Liang HE, Matsumoto I, von Moltke J. Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity. Immunity. 2020 Mar 17;52(3):528-541.e7. doi: 10.1016/j.immuni.2020.02.005. Epub 2020 Mar 10. PubMed PMID: 32160525.
  5. Schwerk J, Soveg FW, Ryan AP, Thomas KR, Hatfield LD, Ozarkar S, Forero A, Kell AM, Roby JA, So L, Hyde JL, Gale M Jr, Daugherty MD, Savan R. Nat Immunol. 2019 Dec;20(12):1610-1620. doi: 10.1038/s41590-019-0527-6. Epub 2019 Nov 18. RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions.
  6. Arroyo EN and Pepper M. B cells, not dendritic cells, prime the dominant CD4+ Tfh response to Plasmodium infection. Journal of Experimental Medicine. In Press.
  7. Wagner CA, Roqué PJ, Mileur TR, Liggitt D, Goverman JM. Myelin-specific CD8 T cells exacerbate brain inflammation in CNS autoimmunity.  J Clin Invest. 2019 Oct 1. pii: 132531. doi: 10.1172/JCI132531. [Epub ahead of print] PMID:31573979
  8. Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs. Roe K, Shu GL, Draves KE, Giordano D, Pepper M, Clark EA. J Immunol. 2019 Oct 1;203(7):1715-1729. doi: 10.4049/jimmunol.1900549. Epub 2019 Sep 4. PMID: 31484732
  9. Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons. Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R.Immunity. 2019 Sep 17;51(3):451-464.e6. doi: 10.1016/j.immuni.2019.07.007. Epub 2019 Aug 27. PMID: 31471108
  10. RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity. Orozco SL, Daniels BP, Yatim N, Messmer MN, Quarato G, Chen-Harris H, Cullen SP, Snyder AG, Ralli-Jain P, Frase S, Tait SWG, Green DR, Albert ML, Oberst A. Cell Rep. 2019 Aug 27;28(9):2275-2287.e5. doi: 10.1016/j.celrep.2019.07.077. PMID: 31461645.
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