Department of Immunology

Immunology News

UW holds No. 4 position on global rankings among US universities

The University of Washington again placed fourth among U.S. higher education institutions, according to the NTU Rankings. For the first time, UW Immunology placed fourth in the world among the subjects at the UW that ranked in the top ten worldwide. The NTU ranking is entirely based on scientific papers, reflecting scientific performance from three perspectives on research — productivity, impact and excellence read more

UW Immunology

The Department of Immunology is a basic science department within the University of Washington, School of Medicine located in Seattle.

Our mission is to advance understanding of the function of the immune system in order to enhance our ability to fight infectious disease, cancer and autoimmune disease.  Basic research of all aspects of immunology is critical to this mission, as well as translational research to link our findings to the development of new therapies.

We hold diversity and inclusiveness as core values in our department and emphasize their importance throughout our research, education and practice. We strive to create a climate that fosters belonging, respect and value for all within our scientific community and the institution.

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Recent Publications

  1. Nat Immunol. 2019 Dec;20(12):1610-1620. doi: 10.1038/s41590-019-0527-6. Epub 2019 Nov 18. RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions. Schwerk J, Soveg FW, Ryan AP, Thomas KR, Hatfield LD, Ozarkar S, Forero A, Kell AM, Roby JA, So L, Hyde JL, Gale M Jr, Daugherty MD, Savan R.
  2. Arroyo EN and Pepper M. B cells, not dendritic cells, prime the dominant CD4+ Tfh response to Plasmodium infection. Journal of Experimental Medicine. In Press.
  3. Myelin-specific CD8 T cells exacerbate brain inflammation in CNS autoimmunity. Wagner CA, Roqué PJ, Mileur TR, Liggitt D, Goverman JM. J Clin Invest. 2019 Oct 1. pii: 132531. doi: 10.1172/JCI132531. [Epub ahead of print] PMID:31573979
  4. Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs. Roe K, Shu GL, Draves KE, Giordano D, Pepper M, Clark EA. J Immunol. 2019 Oct 1;203(7):1715-1729. doi: 10.4049/jimmunol.1900549. Epub 2019 Sep 4. PMID: 31484732
  5. Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons. Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R. Immunity. 2019 Sep 17;51(3):451-464.e6. doi: 10.1016/j.immuni.2019.07.007. Epub 2019 Aug 27. PMID: 31471108
  6. RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity. Orozco SL, Daniels BP, Yatim N, Messmer MN, Quarato G, Chen-Harris H, Cullen SP, Snyder AG, Ralli-Jain P, Frase S, Tait SWG, Green DR, Albert ML, Oberst A. Cell Rep. 2019 Aug 27;28(9):2275-2287.e5. doi: 10.1016/j.celrep.2019.07.077. PMID: 31461645
  7. Cutting Edge: Bacillus Calmette-Guérin-Induced T Cells Shape Mycobacterium tuberculosis Infection before Reducing the Bacterial Burden. Delahaye JL, Gern BH, Cohen SB, Plumlee CR, Shafiani S, Gerner MY, Urdahl KB. J Immunol. 2019 Aug 15;203(4):807-812. doi: 10.4049/jimmunol.1900108. Epub 2019 Jul 15. PMID:31308091
  8. Dendritic cell-associated MAVS is required to control West Nile virus replication and ensuing humoral immune responses. Roe K, Giordano D, Young LB, Draves KE, Holder U, Suthar MS, Gale M Jr, Clark EA. PLoS One. 2019 Jun 26;14(6):e0218928. doi: 10.1371/journal.pone.0218928. eCollection 2019. PMID:31242236
  9. Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus. Hemann EA, Green R, Turnbull JB, Langlois RA, Savan R, Gale M Jr. Nat Immunol. 2019 Aug;20(8):1035-1045. doi: 10.1038/s41590-019-0408-z. Epub 2019 Jun 24. PMID: 31235953
  10. Comparative Analysis of African and Asian Lineage-Derived Zika Virus Strains Reveals Differences in Activation of and Sensitivity to Antiviral Innate Immunity. Esser-Nobis K, Aarreberg LD, Roby JA, Fairgrieve MR, Green R, Gale M Jr. J Virol. 2019 Jun 14;93(13). pii: e00640-19. doi: 10.1128/JVI.00640-19. Print 2019 Jul 1. PMID: 31019057
  11. Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity. Snyder AG, Hubbard NW, Messmer MN, Kofman SB, Hagan CE, Orozco SL, Chiang K, Daniels BP, Baker D, Oberst A. Sci Immunol. 2019 Jun 21;4(36). pii: eaaw2004. doi: 10.1126/sciimmunol.aaw2004. PMID: 31227597
  12. FCRL5+ Memory B Cells Exhibit Robust Recall Responses. Kim CC, Baccarella AM, Bayat A, Pepper M, Fontana MF. Cell Rep. 2019 Apr 30;27(5):1446-1460.e4. doi: 10.1016/j.celrep.2019.04.019. PMID: 31042472
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