Department of Immunology

Ram Savan, Ph.D.

ASSOCIATE PROFESSOR, IMMUNOLOGY

Dr. Ram Savan received his Ph.D. in 2004 from Kagoshima University in Japan.  He completed postdoctoral training in the Laboratory of Experimental Immunology at the National Cancer Institute in 2011.  He  joined the Department of Immunology as an Assistant Professor in  2011 and was promoted to Associate Professor in 2017.

CONTACT

Department of Immunology
University of Washington
Office E307, Box 358059
750 Republican Street
Seattle WA 98109-8059
Phone: 206-221-5141
Fax: 206-685-7120

RESEARCH AREAS

Molecular Immunology
Innate Immunity

LAB MEMBERS

Graduate Students
Frank Soveg, fsoveg@uw.edu
Julian Smith, julianrs@uw.edu
Rachel Van Gelder, rachelvg@uw.edu

Postdoctoral Fellows
Adriana Forero, forera@uw.edu
Nandan Gokhale, ngokhale@uw.edu
Matt Hendricks, mhendric@uw.edu
Lomon So, lomons@uw.edu

Acting Instructor
Johannes Schwerk,
 jschwerk@uw.edu

Staff
Snehal Ozarkar, sneha12@uw.edu

LAB

Website for the Ram Laboratory

Postdoc Position Available

PUBMED

View publication list

 

RESEARCH

Our laboratory is interested in identifying functional non-coding variants that determine susceptibility to life-threatening viral infections such as HCV, HIV, WNV, ZIKA, and influenza.  Identifying novel gene regulatory mechanisms that restrict viruses is critical to developing new therapeutic targets. The three areas of current studies are (i) interferon genetics and biology, (ii) mRNA splicing induced diversity of interferon activated proteome and (iii) control of immune responses through non-coding RNA.  Our laboratory has been at the forefront of genetics and biology of interferons mediating viral restriction. We are investigating the functional consequences of alternative splicing during viral infection. The gene regulatory mechanisms of interests are miRNAs, long non-coding RNAs, SNPs in the non-coding region, mRNA splicing, and RNA structure.

PUBLICATIONS

  1. Schwerk J, Soveg FW, Ryan AP, Thomas KR, Hatfield LD, Ozarkar S, Forero A,
    Kell AM, Roby JA, So L, Hyde JL, Gale M Jr, Daugherty MD, Savan R. RNA-binding
    protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution
    functions. Nat Immunol. 2019 Dec;20(12):1610-1620.
  2. Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So
    L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R.
    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct
    Immune Responses Elicited by Type I and Type III Interferons. Immunity. 2019 Sep
    17;51(3):451-464.e6.
  3. Hemann EA, Green R, Turnbull JB, Langlois RA, Savan R, Gale M Jr. Interferon-λ
    modulates dendritic cells to facilitate T cell immunity during infection with
    influenza A virus. Nat Immunol. 2019 Aug;20(8):1035-1045.
  4. Joslyn RC, Forero A, Green R, Parker SE, Savan R. Long Noncoding RNA
    Signatures Induced by Toll-Like Receptor 7 and Type I Interferon Signaling in
    Activated Human Plasmacytoid Dendritic Cells. J Interferon Cytokine Res. 2018
    Sep;38(9):388-405.
  5. Jarret A, McFarland AP, Horner SM, Kell A, Schwerk J, Hong M, Badil S, Joslyn
    RC, Baker DP, Carrington M, Hagedorn CH, Gale M Jr, Savan R.
    Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral
    signaling. Nat Med. 2016 Dec;22(12):1475-1481.
  6. Hong M, Schwerk J, Lim C, Kell A, Jarret A, Pangallo J, Loo YM, Liu S,
    Hagedorn CH, Gale M Jr, Savan R. Interferon lambda 4 expression is suppressed by
    the host during viral infection. J Exp Med. 2016 Nov 14;213(12):2539-2552.
  7. Lim C, Hong M, Savan R. Human IL-22 binding protein isoforms act as a rheostat
    for IL-22 signaling. Sci Signal. 2016 Sep 27;9(447):ra95.
  8. McFarland AP, Horner SM, Jarret A, Joslyn RC, Bindewald E, Shapiro BA, Delker
    DA, Hagedorn CH, Carrington M, Gale M Jr, Savan R. The favorable IFNL3 genotype
    escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced
    microRNAs. Nat Immunol. 2014 Jan;15(1):72-9.
  9. Kulkarni S, Savan R, Qi Y, Gao X, Yuki Y, Bass SE, Martin MP, Hunt P, Deeks
    SG, Telenti A, Pereyra F, Goldstein D, Wolinsky S, Walker B, Young HA, Carrington
    M. Differential microRNA regulation of HLA-C expression and its association with
    HIV control. Nature. 2011 Apr 28;472(7344):495-8.
  10. Savan R, McFarland AP, Reynolds DA, Feigenbaum L, Ramakrishnan K, Karwan M,
    Shirota H, Klinman DM, Dunleavy K, Pittaluga S, Anderson SK, Donnelly RP, Wilson
    WH, Young HA. A novel role for IL-22R1 as a driver of inflammation. Blood. 2011
    Jan 13;117(2):575-84.