Patrick Mitchell, Ph.D.

ASSISTANT PROFESSOR, MICROBIOLOGY
ADJUNCT ASSISTANT PROFESSOR, IMMUNOLOGY

Patrick is a proud alumnus of Pitzer College. He received his Ph.D. from the University of Washington and the Fred Hutchinson Cancer Research Center under the mentorship of Dr. Harmit Malik and Dr. Michael Emerman studying the evolution of host-virus interactions. Patrick completed his postdoctoral training with Russell Vance at the University of California, Berkeley, where he studied pathogen (both viral and bacterial) detection by a class of host innate immune sensors called inflammasomes.

RESEARCH

Patrick Mitchell, PhD, (he/him) is an Assistant Professor in the Department of Microbiology, Adjunct Assistant Professor in the Department of Immunology, and Freeman Hrabowski Scholar of the Howard Hughes Medical Institute at the University of Washington, School of Medicine. The Mitchell lab is broadly interested in host-pathogen interactions, with a particular focus on ‘effector-triggered immunity’ –  a form of innate immune recognition that is triggered by the detection of pathogen-specific activities. Members of the Mitchell lab are exploring the mechanisms and functional consequences of effector-triggered immunity in host defense and pathogenesis.

PUBLICATIONS

1. Kulsuptrakul, J., Emerman, M., & Mitchell, P. S. (2024). CARD8 inflammasome activation during HIV-1 cell-to-cell transmission. bioRxiv. https://doi.org/10.1101/2024.08.21.608981
2. Tsu, B. V., Agarwal, R., Gokhale, N. S., Kulsuptrakul, J., Ryan, A. P., Fay, E. J., Castro, L. K., Beierschmitt, C., Yap, C., Turcotte, E. A., Delgado-Rodriguez, S. E., Vance, R. E., Hyde, J. L., Savan, R., Mitchell, P. S, & Daugherty, M. D. (2023). Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. PLoS Biol, 21(6), e3002144. https://doi.org/10.1371/journal.pbio.3002144
3. Kulsuptrakul, J., Turcotte, E. A., Emerman, M., & Mitchell, P. S. (2023). A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection. Elife, 12. https://doi.org/10.7554/eLife.84108

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